Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: Implications as a disease biomarker

T Cruickshank; TM Macdonald; SP Walker; E Keenan; K Dane; A Middleton; V Kyritsis; J Myers; C Cluver; R Hastie; L Bergman; D Garcha; P Cannon; E Murray; TV Nguyen; R Hiscock; N Pritchard; NJ Hannan; S Tong; TJ Kaitu’u-Lino

Journal article

Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: Implications as a disease biomarker

T Cruickshank, TM Macdonald, SP Walker, E Keenan, K Dane, A Middleton, V Kyritsis, J Myers, C Cluver, R Hastie, L Bergman, D Garcha, P Cannon, E Murray, TV Nguyen, R Hiscock, N Pritchard, NJ Hannan, S Tong, TJ Kaitu’u-Lino

Journal of the American Heart Association | Published : 2021

DOI: 10.1161/JAHA.120.020302

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Abstract

BACKGROUND: We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly expressed in placenta, to predict preeclampsia. METHODS AND RESULTS: In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF-15 at 36 weeks’ gestation were significantly increased among those who developed preeclampsia (P<0.001), area under the receiver operating characteristic curves (AUC) of 0.66 and 0.71, respectively. In cohort 2 a ratio of sFlt-1/PlGF (a clinical biomarker for preeclampsia) had a sensitivity of 61.0% at 83.2% specificity to predict..

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University of Melbourne Researchers

Teresa MacDonald Author

Susan Walker Author

Emerson Keenan Author

Roxanne Hastie Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854, #116071), the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to MacDonald; National Health and Medical Research Council Fellowships to Kaitu'u--Lino (#1159261), Hannan (#1146128), and Tong (#1136418). The funders played no role in study design or analysis.